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MYP_101937
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Basic Information
C41 [S15X](S15C)
Antimicrobial
Antiviral
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition
not Standard
41 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
EWDREINNYTSLIHXLIEESQNQQEKNEQELLELDKWASLW
Physicochemical Analysis
0.00 Da
0.00
0.00
0.00
0.00
0.00
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0019287 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
noncanonical or undefined residue-containing peptide [Modified]
None
None
PEG2000 conjugated to cysteine substituted at position 15
Bio-Activity Profile
Antiviral Anti-HIV-1 Fusion inhibition
HIV-1 gp41; CHO-WT cells; K562 cells
0.005±0.0005 μM
IC50 (cell-cell fusion inhibition assay)
PaperSite-specific PEGylation of HR2 peptides: effects of PEG conjugation position and chain length on HIV-1 membrane fusion inhibition and proteolytic degradation PMID22770564 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22770564/
RECORD: Rec_0034079 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
noncanonical or undefined residue-containing peptide [Modified]
None
None
PEG750 conjugated to cysteine substituted at position 15
Bio-Activity Profile
Antiviral Anti-HIV-1 Fusion inhibition
HIV-1 gp41; CHO-WT cells; K562 cells
0.0041±0.001 μM
IC50 (cell-cell fusion inhibition assay)
PaperSite-specific PEGylation of HR2 peptides: effects of PEG conjugation position and chain length on HIV-1 membrane fusion inhibition and proteolytic degradation PMID22770564 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22770564/
RECORD: Rec_0281488 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Cathelicidin
32630
Structure & Mods
linear peptide [Linear]
noncanonical or undefined residue-containing peptide [Modified]
PEG conjugated to cysteine substituted at position 15; PEG chain length unresolved in this CAMP record
Bio-Activity Profile
Antiviral Anti-HIV-1 Fusion inhibition
HIV-1 gp41; CHO-WT cells; K562 cells
IC50 (cell-cell fusion inhibition assay)
PaperSite-specific PEGylation of HR2 peptides: effects of PEG conjugation position and chain length on HIV-1 membrane fusion inhibition and proteolytic degradation PMID22770564 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22770564/
RECORD: Rec_0341471 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
HR2 fusion-inhibitory peptide
32630
Structure & Mods
linear peptide [Linear]
modified L-amino-acid peptide [Modified]
None
None
PEG750 conjugated to cysteine substituted at position 15
Bio-Activity Profile
Antiviral Anti-HIV-1 Fusion inhibition
HIV-1 gp41; CHO-WT cells; K562 cells
0.0041±0.001 μM
IC50 (cell-cell fusion inhibition assay)
Mammalian: 1 h; Yeast: 30 min; E. coli: >10 h
PaperSite-specific PEGylation of HR2 peptides: effects of PEG conjugation position and chain length on HIV-1 membrane fusion inhibition and proteolytic degradation PMID22770564 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22770564/
RECORD: Rec_0360086 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
HR2 fusion-inhibitory peptide
32630
Structure & Mods
linear peptide [Linear]
modified L-amino-acid peptide [Modified]
None
None
PEG2000 conjugated to cysteine substituted at position 15
Bio-Activity Profile
Antiviral Anti-HIV-1 Fusion inhibition
HIV-1 gp41; CHO-WT cells; K562 cells
0.005±0.0005 μM
IC50 (cell-cell fusion inhibition assay)
Mammalian: 1 h; Yeast: 30 min; E. coli: >10 h
PaperSite-specific PEGylation of HR2 peptides: effects of PEG conjugation position and chain length on HIV-1 membrane fusion inhibition and proteolytic degradation PMID22770564 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22770564/