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MYP_101928
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Basic Information
Epilancin 15X(Bacteriocin)
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Standard
31 amino acids
C145H248N42O40S3
Standard
Sequence
SASIVKTTIKASKKLCRGFTLTCGCHFTGKK
Physicochemical Analysis
3315.97 Da
10.07
6.51
6.20
0.2101
-0.02
0.75
-0.03
-0.51
66.13
0.0645
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1344.86
-16.12
53.0
51.0
115.0
230.0
3.0
30.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0043718 VERIFIED: YES
Provenance & Taxonomy
Staphylococcus epidermidis [Bacterium]
Bacteriocin
1282
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Gram-positive
PaperPubMed PMID: 15792796 | PubMed PMID: 21802007 PMID15792796;21802007 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15792796/
RECORD: Rec_0050420 VERIFIED: YES
Provenance & Taxonomy
Staphylococcus epidermidis [Bacterium]; Bacteria [Bacterium]
2; 2
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PMID16569864 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16569864/
RECORD: Rec_0252477 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial
PaperYADAMP: yet another database of antimicrobial peptides PMID22325123 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22325123/
RECORD: Rec_0297095 VERIFIED: YES
Provenance & Taxonomy
Staphylococcus epidermidis [Bacterium]
Bacteriocin
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
The 5 gene cluster elxABCOP, one for export and three for immunity, has been found. The production is media condition dependent. The medium containing 10% Lab-Lemco meat extract, 2% NaCl, 20 mM NH4Cl, 3% malt extract, and 0.4% Ca(OH)2 produced the highest concentration of epilancin 15X at 3 mg/L (Velásquez et al., 2011). Chemical modification: There are three thioether rings: S12-C16, T20-C23, and T22-C25. In addition, S2, T7, T8, and T28 are dehydrated. Finally, the N-terminus of the peptide is hydroxyl-propionylated (Hop, similar to acetylation). The 2011 paper reported the N-terminal D-lactate is converted from a serine residue modified by enzymes. Peptide stability: the lactate form is protected from degradation by aminopeptidase
Bio-Activity Profile
Antimicrobial
bacteriostatic, and Bacillus megaterium
0.1 μM
MIC
PaperIsolation and structural characterization of epilancin 15X, a novel lantibiotic from a clinical strain of Staphylococcus epidermidis
RECORD: Rec_0297155 VERIFIED: YES
Provenance & Taxonomy
Staphylococcus epidermidis [Bacterium]
type A lantibiotic family
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
1-Ser: Lactic acid; 3-Ser: 2,3-didehydroalanine (Ser); 7-Thr: 2,3-didehydrobutyrine; 8-Thr: 2,3-didehydrobutyrine; 28-Thr: 2,3-didehydrobutyrine
Bio-Activity Profile
Antimicrobial type A lantibiotic family Antibacterial Host defense
PaperPDB 1W9N structural record; NMR; chain A; residues 2-31
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