Peptide Database

Peptide NameEsculentin-1PLa

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Standard StatusStandard

Sequence Length46 amino acids

Chemical FormulaC220H378N60O61S3

DescriptionStandard

        GLFPKINKKKAKTGVFNIIKTVGKEAGMDLIRTGIDTIGCKIKGEC
    

Molecular Weight4935.92 Da

Isoelectric Point (pI)9.76

Net Charge (pH 7.0)5.74

Net Charge (pH 7.4) 5.49

Charge Density (pH 7.0) 0.1248

GRAVY Index-0.09

Hydrophobic Moment 0.66

Boman Index0.03

Instability Index14.86

Aliphatic Index 93.26

Aromaticity 0.0435

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 125.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1976.41

LogP -17.62

H-bond Donors 70.0

H-bond Acceptors 70.0

Rotatable Bonds 177.0

Heavy Atoms 344.0

Ring Count 3.0

Amide Bonds 47.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0306885 VERIFIED: YES

Provenance & Taxonomy

OrganismLithobates palustris [Animal]

FamilyEsculentin

Structure & Mods

ConfigLinear peptide with a single intramolecular disulfide-stabilized loop [Linear]

ChiralityGene-encoded natural peptide composed of standard L-amino acids [L]

Disulfide40-46

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive

TargetStaphylococcus aureus

Activity12.0 μM

MethodMIC

PaperY.J. Basir et al. / Biochimica et Biophysica Acta 1543 (2000) 95-105. Multiple antimicrobial peptides and peptides related to bradykinin and neuromedin N isolated from skin secretions of the pickerel frog, Rana palustris PMID11087945 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11087945/

RECORD: Rec_0408776 VERIFIED: YES

Provenance & Taxonomy

OrganismRana palustris [Animal]

FamilyEsculentin

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermCyclization

Disulfide40-46

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative

TargetEscherichia coli

Activity1 μM

MethodMIC

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