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MYP_101926
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Basic Information
Esculentin-1PLa
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Standard
46 amino acids
C220H378N60O61S3
Standard
Sequence
GLFPKINKKKAKTGVFNIIKTVGKEAGMDLIRTGIDTIGCKIKGEC
Physicochemical Analysis
4935.92 Da
9.76
5.74
5.49
0.1248
-0.09
0.66
0.03
14.86
93.26
0.0435
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1976.41
-17.62
70.0
70.0
177.0
344.0
3.0
47.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0000042 VERIFIED: YES
Provenance & Taxonomy
Pickerel frog [Animal]
Esculentin
33208
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
40-46
Bio-Activity Profile
Antimicrobial
PMID11087945 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11087945/
RECORD: Rec_0013749 VERIFIED: YES
Provenance & Taxonomy
Lithobates palustris [Animal]
Esculentin
298395
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
40-46
Bio-Activity Profile
Antimicrobial
Staphylococcus aureus
12 μM
MIC
PaperMultiple antimicrobial peptides and peptides related to bradykinin and neuromedin N isolated from skin secretions of the pickerel frog, Rana palustris. PMID11087945 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11087945/
RECORD: Rec_0015131 VERIFIED: NO
Provenance & Taxonomy
Rana palustris [Animal]
Esculentin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
RECORD: Rec_0037229 VERIFIED: YES
Provenance & Taxonomy
Lithobates palustris [Animal]
Esculentin
Structure & Mods
Linear peptide with a single intramolecular disulfide-stabilized loop [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
40-46
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
Escherichia coli
1.0 μM
MIC
PaperY.J. Basir et al. / Biochimica et Biophysica Acta 1543 (2000) 95-105. Multiple antimicrobial peptides and peptides related to bradykinin and neuromedin N isolated from skin secretions of the pickerel frog, Rana palustris PMID11087945 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11087945/
RECORD: Rec_0063930 VERIFIED: YES
Provenance & Taxonomy
Lithobates palustris [Animal]
Esculentin
298395
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
40-46
Bio-Activity Profile
Antimicrobial
but not Candida albicans
>150 μM
MIC
PaperMultiple antimicrobial peptides and peptides related to bradykinin and neuromedin N isolated from skin secretions of the pickerel frog, Rana palustris. PMID11087945 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11087945/
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