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MYP_101904
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Basic Information
Unnamed
Cardiovascular ▸ Blood pressure regulation ▸ Antihypertensive
Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory
Membrane / Ion-channel modulation ▸ Calcium channel modulation ▸ Calcium channel inhibitor
Neurological / Signaling ▸ Analgesic/opioid activity ▸ Opioid antagonist
Sensory / Food function ▸ Taste-active peptide ▸ Bitter peptide
Standard
7 amino acids
C46H59N7O12
Standard
Sequence
AYFYPEL
Physicochemical Analysis
902.00 Da
4.05
-1.20
-1.40
-0.1719
0.10
0.25
0.40
97.60
70.00
0.4286
2980.00
2980.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
306.89
0.88
10.0
11.0
23.0
65.0
4.0
6.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0183907 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
alpha-S1-Casein-derived
9913
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
ACE inhibitory Antihypertensive
Angiotensin-converting enzyme (ACE)
6.58 μM
IC50
PaperNovel casein-derived peptides with antihypertensive activity | Contreras, M. del Mar. et al. | DOI: 10.1016/j.idairyj.2009.05.004 Evidence URLhttps://www.uniprot.org/uniprotkb/P02662/entry
RECORD: Rec_0215536 VERIFIED: NO
Provenance & Taxonomy
Bos taurus [Animal]; synthetic construct [Synthetic]; Hydrolysis with [Plant]; Miso paste [Plant]; Fabaceae [Plant]
9913; 32630; 33090; 33090; 3803
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antihypertensive
PaperIsolation and characterization of peptides with antihypertensive activity in foodstuffs PMID24915368 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24915368/
RECORD: Rec_0233714 VERIFIED: YES
Provenance & Taxonomy
Brassica napus [Plant]
ACE-inhibitory peptide
3708
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antihypertensive
PaperGlycinyl-Histidinyl-Serine (GHS), a Novel Rapeseed Protein-Derived Peptide Has Blood Pressure-Lowering Effect in Spontaneously Hypertensive Rats PMID23919612 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23919612/
RECORD: Rec_0251398 VERIFIED: NO
Provenance & Taxonomy
Bos taurus [Animal]
Casein-derived peptide
9913
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antihypertensive
RECORD: Rec_0336166 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
9913.0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antihypertensive ACE inhibitory
Angiotensin-converting enzyme (ACE)
6.58
IC50
PaperStuknyte M., Cattaneo S., Masotti F., De Noni I.. Occurrence and fate of ACE-inhibitor peptides in cheeses and in their digestates following in vitro static gastrointestinal digestion. Food Chemistry, 168, 27-33.
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