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MYP_101762
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Basic Information
Sapecin C
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
40 amino acids
C171H279N57O51S6
Standard
Sequence
ATCDLLSGIGVQHSACALHCVFRGNRGGYCTGKGICVCRN
Physicochemical Analysis
4141.79 Da
8.69
2.91
2.53
0.0727
0.28
0.54
0.10
17.00
78.00
0.0500
1490.00
1865.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1735.02
-23.16
68.0
62.0
135.0
285.0
4.0
42.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0023094 VERIFIED: YES
Provenance & Taxonomy
Sarcophaga peregrina [Animal]
Defensin
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Three disulfid bonds: 3,30; 16,36; 20,38
Bio-Activity Profile
Antimicrobial
S. bovis ATCC 27960t
2.4 μg/mL
IC50
PaperPurification, sequence and antibacterial activity of two novel sapecin homologues from Sarcophaga embryonic cells: similarity of sapecin B to charybdotoxin.
RECORD: Rec_0061852 VERIFIED: YES
Provenance & Taxonomy
Sarcophaga peregrina [Animal]
Defensin
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Three disulfid bonds: 3,30; 16,36; 20,38
Bio-Activity Profile
Antimicrobial
S. mutans 6515t
2.6 μg/mL
IC50
PaperPurification, sequence and antibacterial activity of two novel sapecin homologues from Sarcophaga embryonic cells: similarity of sapecin B to charybdotoxin.
RECORD: Rec_0064418 VERIFIED: YES
Provenance & Taxonomy
Sarcophaga peregrina [Animal]
Defensin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
disulfide bond; sites not specified
Bio-Activity Profile
Antimicrobial Defensin Cytotoxic Non-hemolytic
PMID8471044 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8471044/
RECORD: Rec_0077192 VERIFIED: YES
Provenance & Taxonomy
Sarcophaga peregrina [Animal]
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Corynebacterium glutamicum
PaperPubMed PMID: 8471044 PMID8471044 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8471044/
RECORD: Rec_0093419 VERIFIED: YES
Provenance & Taxonomy
Sarcophaga peregrina [Animal]
Defensin
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Three disulfid bonds: 3,30; 16,36; 20,38
Bio-Activity Profile
Antimicrobial
Staphylococcus aureus MR1587
0.9 μg/mL
IC50
PaperPurification, sequence and antibacterial activity of two novel sapecin homologues from Sarcophaga embryonic cells: similarity of sapecin B to charybdotoxin.
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