Peptide Database

Peptide NameSLAY-screened peptide P1346

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC109H168N30O29

DescriptionStandard

        LYHARLYRLYLVASVDSVHS
    

Molecular Weight2362.68 Da

Isoelectric Point (pI)8.51

Net Charge (pH 7.0)0.93

Net Charge (pH 7.4) 0.62

Charge Density (pH 7.0) 0.0466

GRAVY Index0.31

Hydrophobic Moment 0.36

Boman Index0.11

Instability Index9.33

Aliphatic Index 131.50

Aromaticity 0.1500

Extinction Coeff. Reduced 4470.00

Extinction Coeff. Oxidized 4470.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 956.06

LogP -6.44

H-bond Donors 36.0

H-bond Acceptors 32.0

Rotatable Bonds 73.0

Heavy Atoms 168.0

Ring Count 5.0

Amide Bonds 19.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0130129 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/