Peptide Database

Peptide NameSLAY-screened peptide P4052

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length21 amino acids

Chemical FormulaC124H167N27O29S

DescriptionStandard

        VRPSPFFYFSRYPCGATPYLY
    

Molecular Weight2531.88 Da

Isoelectric Point (pI)9.11

Net Charge (pH 7.0)1.72

Net Charge (pH 7.4) 1.49

Charge Density (pH 7.0) 0.0819

GRAVY Index-0.12

Hydrophobic Moment 0.35

Boman Index0.15

Instability Index77.31

Aliphatic Index 37.14

Aromaticity 0.3333

Extinction Coeff. Reduced 5960.00

Extinction Coeff. Oxidized 5960.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 875.57

LogP -4.18

H-bond Donors 32.0

H-bond Acceptors 32.0

Rotatable Bonds 66.0

Heavy Atoms 181.0

Ring Count 11.0

Amide Bonds 20.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0136690 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/