Peptide Database

Peptide NameBactericidal permeability-increasing protein

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length507 amino acids

Chemical FormulaC2566H4032N644O743S11

DescriptionStandard

        MHEKTVHVLWGYFLLWNLHIASSQTVHPGIKARATQRALDYGVQAGREIIEQMVKERKIPDLKGNESLEFLKIDYVNYNFSNIKINAFSFPNTSLAFVPGVGIKVLTNHGTTNISTDWEVKSPLFQDTGGADLFLSGVYFTGVLILARNDFGQPTVKLQDCYAQVSHAQVSFSGELKVLYNSFAEPMEKPILRNLNEILCPIITSEVEALNANLSVLEVLTKIDNYTLLDYSLISSPEITENYLDLNLKGVFYPLENLTDPPFSPVPIVLPERSDSMLYIGLSKYFFKSASFAYFTAGAFNVTLSTKEISSHLIPNSQGLGSMLSRLAEIYILSQPLMVRIMATEPPVISLLPGNFTLDIPASIIILTQAENSTAETIVSMDFVASTSVGLVILGQRLICSLSLNRFRLSLPESSRGSIEVLRFENILSSIIHFGVLPLANAKLQQGFPLPHPHKISFVNSDVEVLEDLLLISTNLKYETSLKQPPSFPGWADLNLISRQLSGKPAP
    

Molecular Weight56144.05 Da

Isoelectric Point (pI)5.55

Net Charge (pH 7.0)-9.59

Net Charge (pH 7.4) -10.48

Charge Density (pH 7.0) -0.0189

GRAVY Index0.15

Hydrophobic Moment 0.77

Boman Index0.17

Instability Index38.54

Aliphatic Index 108.82

Aromaticity 0.0927

Extinction Coeff. Reduced 45840.00

Extinction Coeff. Oxidized 45965.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0284751 VERIFIED: NO

Provenance & Taxonomy

OrganismEquus caballus [Animal]

FamilyBPI/LBP

Tax ID9796

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic Non-ribosomal

TargetGram-negative bacteria

MethodQualitative functional evidence