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MYP_101588
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Basic Information
DFT512
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Standard
13 amino acids
C61H112N14O16
Standard
Sequence
GLLSLLSLLGKAL
Physicochemical Analysis
1297.63 Da
8.75
0.76
0.55
0.0584
1.70
0.43
0.55
2.70
217.69
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
479.00
-2.07
17.0
17.0
45.0
91.0
0.0
12.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0209218 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Pseudomonas aeruginosa PAO1
25 μM
MIC
PaperLow cationicity is important for systemic in vivo efficacy of database-derived peptides against drug-resistant Gram-positive pathogens PMID31209048 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31209048/
RECORD: Rec_0249923 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Klebsiella pneumoniae
3.1 μM
MIC
PaperLow cationicity is important for systemic in vivo efficacy of database-derived peptides against drug-resistant Gram-positive pathogens PMID31209048 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31209048/
RECORD: Rec_0352209 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus USA 300
0.78 μM
MIC
PaperLow cationicity is important for systemic in vivo efficacy of database-derived peptides against drug-resistant Gram-positive pathogens PMID31209048 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31209048/
RECORD: Rec_0379850 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
APD analysis reveals that this sequence is poorly similar (92.31%) to DFTamP1 . L: 54%; G=S: 15%. Chemical modification: C-terminal amidation
Bio-Activity Profile
Antimicrobial
Klebsiella pneumoniae ATCC 13883
3.1 μM
MIC
PaperLow cationicity is important for systemic in vivo efficacy of database-derived peptides against drug-resistant Gram-positive pathogens PMID31209048 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31209048/
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