Peptide Database

Peptide NameSLAY-screened peptide P4648

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length21 amino acids

Chemical FormulaC106H169N33O29S

DescriptionStandard

        PPKGRRICYLHVPHDLPTSTN
    

Molecular Weight2401.74 Da

Isoelectric Point (pI)9.37

Net Charge (pH 7.0)2.12

Net Charge (pH 7.4) 1.95

Charge Density (pH 7.0) 0.1011

GRAVY Index-0.85

Hydrophobic Moment 0.34

Boman Index-0.15

Instability Index53.11

Aliphatic Index 69.52

Aromaticity 0.0476

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1490.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 973.45

LogP -9.97

H-bond Donors 35.0

H-bond Acceptors 34.0

Rotatable Bonds 71.0

Heavy Atoms 169.0

Ring Count 7.0

Amide Bonds 21.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0235604 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/