Peptide Database

Peptide NameSLAY-screened peptide P2911

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length21 amino acids

Chemical FormulaC97H144N22O32S2

DescriptionStandard

        IGGYSPSDATYTIVCFMPNGT
    

Molecular Weight2194.44 Da

Isoelectric Point (pI)4.05

Net Charge (pH 7.0)-1.25

Net Charge (pH 7.4) -1.47

Charge Density (pH 7.0) -0.0596

GRAVY Index0.21

Hydrophobic Moment 0.28

Boman Index0.31

Instability Index43.09

Aliphatic Index 55.71

Aromaticity 0.1429

Extinction Coeff. Reduced 2980.00

Extinction Coeff. Oxidized 2980.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 849.74

LogP -9.93

H-bond Donors 30.0

H-bond Acceptors 33.0

Rotatable Bonds 63.0

Heavy Atoms 153.0

Ring Count 5.0

Amide Bonds 21.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0158196 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/