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MYP_101517
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Basic Information
hepcidin
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Standard
20 amino acids
C92H153N35O21S9
Standard
Sequence
CRFCCRCCPRMRGCGLCCRF
Physicochemical Analysis
2374.01 Da
9.01
4.68
4.36
0.2340
0.32
0.65
-0.26
7.34
19.50
0.1000
0.00
500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
916.93
-10.58
43.0
35.0
75.0
157.0
3.0
19.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0066883 VERIFIED: NO
Provenance & Taxonomy
Actinopterygii [Animal]
Hepcidin
7898
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
RECORD: Rec_0075345 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Hepcidin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0129448 VERIFIED: YES
Provenance & Taxonomy
Sparus aurata [Animal]
Hepcidin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal
two seabream isolates Pdp11
2.2 μM
IC50
PaperThe antimicrobial peptide hepcidin exerts an important role in the innate immunity against bacteria in the bony fish giltherad seabream
RECORD: Rec_0169285 VERIFIED: YES
Provenance & Taxonomy
Acanthopagrus schlegelii [Animal]
Hepcidin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
Escherichia coli
10 μM
MIC
RECORD: Rec_0188725 VERIFIED: YES
Provenance & Taxonomy
Acanthopagrus schlegelii [Animal]
Hepcidin
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
51M6
14.61 μM
IC50
PaperPubMed PMID: 18164062 PMID18164062 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18164062/
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