Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length139 amino acids

Chemical FormulaC681H1106N188O188S4

DescriptionStandard

        PAELPVAPEPTLLLAITDLVANSAALVYFTAGALRRNISADMIPRRFPLQLKTKSMGVFSPQLQKHFPDQPMELLLSARRQPLLSCHPDALHGTLFSSAEAFVVLPNATRVPAFLLNIDANVTGKPTISRNRLGGTVKL
    

Molecular Weight15063.47 Da

Isoelectric Point (pI)10.01

Net Charge (pH 7.0)5.22

Net Charge (pH 7.4) 4.98

Charge Density (pH 7.0) 0.0376

GRAVY Index0.15

Hydrophobic Moment 0.52

Boman Index0.11

Instability Index57.76

Aliphatic Index 106.04

Aromaticity 0.0576

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1490.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 5918.16

LogP -54.92

H-bond Donors 202.0

H-bond Acceptors 200.0

Rotatable Bonds 482.0

Heavy Atoms 1061.0

Ring Count 25.0

Amide Bonds 149.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0404983 VERIFIED: NO

Provenance & Taxonomy

OrganismAegotheles bennettii [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria