Peptide Database

Peptide NameSLAY-screened peptide P742

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length15 amino acids

Chemical FormulaC74H105N21O23

DescriptionStandard

        ASSHYNRGSYLAFPS
    

Molecular Weight1656.75 Da

Isoelectric Point (pI)8.64

Net Charge (pH 7.0)0.88

Net Charge (pH 7.4) 0.64

Charge Density (pH 7.0) 0.0587

GRAVY Index-0.59

Hydrophobic Moment 0.29

Boman Index0.01

Instability Index71.49

Aliphatic Index 39.33

Aromaticity 0.2000

Extinction Coeff. Reduced 2980.00

Extinction Coeff. Oxidized 2980.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 716.98

LogP -9.38

H-bond Donors 26.0

H-bond Acceptors 25.0

Rotatable Bonds 48.0

Heavy Atoms 118.0

Ring Count 5.0

Amide Bonds 15.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0154469 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/