Peptide Database

Peptide NameWQ-IDI(628-656)

Function Ontology

Antimicrobial

Antiviral

Antiviral ▸ Anti-HIV ▸ Anti-HIV-1

Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition

Standard StatusStandard

Sequence Length29 amino acids

Chemical FormulaC167H263N41O53

DescriptionStandard

        WEEWDKKIEEYTKKIEELIKKSQNQQIDI
    

Molecular Weight3693.12 Da

Isoelectric Point (pI)4.86

Net Charge (pH 7.0)-2.23

Net Charge (pH 7.4) -2.45

Charge Density (pH 7.0) -0.0768

GRAVY Index-1.51

Hydrophobic Moment 0.69

Boman Index-0.31

Instability Index64.54

Aliphatic Index 80.69

Aromaticity 0.1034

Extinction Coeff. Reduced 12490.00

Extinction Coeff. Oxidized 12490.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1597.27

LogP -10.40

H-bond Donors 53.0

H-bond Acceptors 51.0

Rotatable Bonds 134.0

Heavy Atoms 261.0

Ring Count 5.0

Amide Bonds 32.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0278756 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyFusion-inhibitory peptide

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antiviral Anti-HIV-1 Fusion inhibition

Targetinhibition of peptide against cell-cell fusion between H9/HIV-1 IIIB cells and MT-2 cells

Activity0.0064±0.0018 μM

MethodIC50

Half-LifeMammalian: 2.8 h; Yeast: 3 min; E. coli: 2 min

PaperCreating an Artificial Tail Anchor as a Novel Strategy To Enhance the Potency of Peptide-Based HIV Fusion Inhibitors. | Su S, Zhu Y, Ye S, Qi Q, Xia S, Ma Z, Yu F, Wang Q, Zhang R, Jiang S, Lu L. | J Virol. 2016 Dec 16;91(1):e01445-16. | DOI:10.1128/JVI.01445-16 | PMID:27795416 PMID27795416 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27795416/

RECORD: Rec_0326411 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antimicrobial Antiviral

TargetHIV-1 Bal:inhibition of virus infection in MT-2 cells

Activity0.0032±0.0002 μM

MethodIC50

RECORD: Rec_0369917 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antiviral

TargetHIV-1 IIIB

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