Peptide Database

Peptide NameCopsin

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Standard StatusStandard

Sequence Length57 amino acids

Chemical FormulaC238H398N88O76S12

DescriptionStandard

        QNCPTRRGLCVTSGLTACRNHCRSCHRGDVGCVRCSNAQCTGFLGTTCTCINPCPRC
    

Molecular Weight6093.03 Da

Isoelectric Point (pI)8.86

Net Charge (pH 7.0)5.82

Net Charge (pH 7.4) 5.34

Charge Density (pH 7.0) 0.1020

GRAVY Index-0.21

Hydrophobic Moment 0.69

Boman Index-0.14

Instability Index50.53

Aliphatic Index 46.14

Aromaticity 0.0175

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 750.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 2655.35

LogP -42.63

H-bond Donors 107.0

H-bond Acceptors 96.0

Rotatable Bonds 193.0

Heavy Atoms 414.0

Ring Count 6.0

Amide Bonds 62.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0174046 VERIFIED: YES

Provenance & Taxonomy

OrganismCoprinopsis cinerea [Fungus]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Lipid II binding Peptidoglycan synthesis inhibition

TargetStaphylococcus epidermidis DSM 20044

Activity64 μg/mL

MethodMIC

RECORD: Rec_0204536 VERIFIED: YES

Provenance & Taxonomy

OrganismCoprinopsis cinerea [Fungus]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Lipid II binding Peptidoglycan synthesis inhibition

TargetEscherichia coli BL21

Activity64 μg/mL

MethodMIC

RECORD: Rec_0252931 VERIFIED: YES

Provenance & Taxonomy

OrganismCoprinopsis cinerea [Fungus]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Lipid II binding Peptidoglycan synthesis inhibition

TargetEnterococcus faecium VRE DSM 13590

Activity2 μg/mL

MethodMIC

RECORD: Rec_0272820 VERIFIED: YES

Provenance & Taxonomy

OrganismCoprinopsis cinerea [Fungus]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Lipid II binding Peptidoglycan synthesis inhibition

TargetStreptococcus pyogenes DSM 20565

MethodQualitative antimicrobial activity evidence

RECORD: Rec_0290674 VERIFIED: YES

Provenance & Taxonomy

OrganismCoprinopsis cinerea [Fungus]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Lipid II binding Peptidoglycan synthesis inhibition

TargetStreptococcus pneumoniae DSM 20566

MethodQualitative antimicrobial activity evidence

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