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MYP_101315
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Basic Information
Copsin
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Standard
57 amino acids
C238H398N88O76S12
Standard
Sequence
QNCPTRRGLCVTSGLTACRNHCRSCHRGDVGCVRCSNAQCTGFLGTTCTCINPCPRC
Physicochemical Analysis
6093.03 Da
8.86
5.82
5.34
0.1020
-0.21
0.69
-0.14
50.53
46.14
0.0175
0.00
750.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
2655.35
-42.63
107.0
96.0
193.0
414.0
6.0
62.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0019277 VERIFIED: YES
Provenance & Taxonomy
Coprinopsis cinerea [Fungus]
33208; 33208
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Lipid II binding Peptidoglycan synthesis inhibition Antibacterial
Lipid II
Lipid II binding assay
PaperCopsin, a novel peptide-based fungal antibiotic interfering with the peptidoglycan synthesis. J Biol Chem. 2014. PMID:25342741. PMID25342741 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25313391/
RECORD: Rec_0036685 VERIFIED: YES
Provenance & Taxonomy
Coprinopsis cinerea [Fungus]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Lipid II binding Peptidoglycan synthesis inhibition
Listeria innocua WSLC 2012
0.5 μg/mL
MIC
PaperEssig A, Hofmann D, Münch D, et al. Copsin, a novel peptide-based fungal antibiotic interfering with the peptidoglycan synthesis. J Biol Chem. 2014;289(50):34953-34964. DOI:10.1074/jbc.M114.599878. PMID:25342741. PMID25342741 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25342741/
RECORD: Rec_0063157 VERIFIED: YES
Provenance & Taxonomy
Coprinopsis cinerea [Fungus]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Lipid II binding Peptidoglycan synthesis inhibition
Staphylococcus aureus 113 DSM 4910
64 μg/mL
MIC
PaperEssig A, Hofmann D, Münch D, et al. Copsin, a novel peptide-based fungal antibiotic interfering with the peptidoglycan synthesis. J Biol Chem. 2014;289(50):34953-34964. DOI:10.1074/jbc.M114.599878. PMID:25342741. PMID25342741 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25342741/
RECORD: Rec_0086957 VERIFIED: YES
Provenance & Taxonomy
Coprinopsis cinerea [Fungus]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Lipid II binding Peptidoglycan synthesis inhibition
Staphylococcus aureus ATCC 29213
40 μg/mL
MIC
PaperEssig A, Hofmann D, Münch D, et al. Copsin, a novel peptide-based fungal antibiotic interfering with the peptidoglycan synthesis. J Biol Chem. 2014;289(50):34953-34964. DOI:10.1074/jbc.M114.599878. PMID:25342741. PMID25342741 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25342741/
RECORD: Rec_0097301 VERIFIED: YES
Provenance & Taxonomy
Coprinopsis cinerea [Fungus]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Lipid II binding Peptidoglycan synthesis inhibition
Staphylococcus carnosus DSM 20501
8 μg/mL
MIC
PaperEssig A, Hofmann D, Münch D, et al. Copsin, a novel peptide-based fungal antibiotic interfering with the peptidoglycan synthesis. J Biol Chem. 2014;289(50):34953-34964. DOI:10.1074/jbc.M114.599878. PMID:25342741. PMID25342741 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25342741/
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