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MYP_101100
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Basic Information
Casoparan
Anticancer
Anticancer ▸ Apoptosis induction
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Hormonal / Endocrine ▸ Hormone peptide
Immunology ▸ Immune modulation ▸ Immunostimulatory activity
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
5 amino acids
C28H54N8O7
Standard
Sequence
INKKI
Physicochemical Analysis
614.78 Da
10.00
1.76
1.55
0.3516
-0.46
0.75
-0.20
38.38
156.00
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
274.85
-1.44
9.0
9.0
23.0
43.0
0.0
5.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0175857 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
9913.0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anticancer
B16F10 melanoma cells
PaperAzevedo R. A., Ferreira A. K., Auada A. V. V., Pasqualoto K. F. M., Marques-Porto R., Maria D. A., Lebrun I.. Antitumor effect of cationic INKKI peptide from bovine beta-casein on melanoma B16F10. J. Cancer Therapy, 3, 237-244, 2012.
RECORD: Rec_0245725 VERIFIED: YES
Provenance & Taxonomy
β-Casein [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anticancer Hemolytic
Evidence URLhttps://dramp.cpu-bioinfor.org/browse/All_Information.php?dataset=General&id=DRAMP32373
RECORD: Rec_0253262 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
beta-Casein-derived
9913
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anticancer Cytotoxic Pro-apoptotic
Mice
1.7 μM
PaperAntitumor Effect of Cationic INKKI Peptide from Bovine β-Casein on Melanoma B16F10 | Azeveda, RA. et al. | DOI: 10.4236/jct.2012.34034 Evidence URLhttps://www.uniprot.org/uniprotkb/P02666/entry
RECORD: Rec_0352071 VERIFIED: YES
Provenance & Taxonomy
β-Casein [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anticancer
MCF-7
3.07 μg/mL
IC50
Evidence URLhttps://dramp.cpu-bioinfor.org/browse/All_Information.php?dataset=General&id=DRAMP32373
RECORD: Rec_0400744 VERIFIED: YES
Provenance & Taxonomy
β-Casein [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anticancer
T-47D
3.26 μg/mL
IC50
Evidence URLhttps://dramp.cpu-bioinfor.org/browse/All_Information.php?dataset=General&id=DRAMP32373
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