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MYP_101067
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Basic Information
CHOL-C-Temporin L[Pro3,DLeu9,Nle10](TL6.3)
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antifungal
Antiviral
Antiviral ▸ Anti-Coronavirus ▸ Anti-SARS-CoV-2
Antiviral ▸ Anti-Herpesvirus ▸ Anti-HSV
Antiviral ▸ Anti-Influenza virus
Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition
Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
not Standard
14 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
CFVPWFSKFLXRIL
Physicochemical Analysis
0.00 Da
0.00
0.00
0.00
0.00
0.00
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0077358 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Temporin
32630
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Cholesterol-PEG4
Amidation
The 'X' at position 10 is norleucine
Bio-Activity Profile
Antimicrobial Antiviral
influenza virus(H1N1,VR-1894):inhibition of replication in MDKC cells
2.55 μM
IC50
PaperBroad-Spectrum Antiviral Activity of the Amphibian Antimicrobial Peptide Temporin L and Its Analogs PMID35216177 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35216177/
RECORD: Rec_0078853 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Cholesterol-PEG4
Nle, N-terminal: Cholesterol-PEG4, C- terminal: NH2, small case letters are D amino acids at 11; Nle, N-terminal: Cholesterol-PEG4, C- terminal: NH2, small case letters are D amino acids
Bio-Activity Profile
Antimicrobial Antifungal
influenza virus
2.55 μM
IC50
PMID35216177 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35216177/
RECORD: Rec_0124473 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Cholesterol-PEG4
Nle, N-terminal: Cholesterol-PEG4, C- terminal: NH2, small case letters are D amino acids at 11; Nle, N-terminal: Cholesterol-PEG4, C- terminal: NH2, small case letters are D amino acids
Bio-Activity Profile
Antimicrobial Antifungal
SARS-CoV-2
0.76 μM
IC50
PMID35216177 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35216177/
RECORD: Rec_0126101 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Cholesterol-PEG4
Nle, N-terminal: Cholesterol-PEG4, C- terminal: NH2, small case letters are D amino acids at 11; Nle, N-terminal: Cholesterol-PEG4, C- terminal: NH2, small case letters are D amino acids
Bio-Activity Profile
Antimicrobial Antifungal
HSV-1
0.89 μM
IC50
PMID35216177 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35216177/
RECORD: Rec_0200008 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Temporin
32630
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Cholesterol-PEG4
Amidation
The 'X' at position 10 is norleucine.; Cholesterol-PEG4
Bio-Activity Profile
Antiviral Anti-Influenza virus Replication inhibition
Influenza virus (H1N1,VR-1894) | MDCK cells
2.55 μM
IC50
Mammalian: 1.2 h; Yeast: >20 h; E. coli: >10 h
PaperBroad-Spectrum Antiviral Activity of the Amphibian Antimicrobial Peptide Temporin L and Its Analogs. | Zannella C, Chianese A, Palomba L, Marcocci ME, Bellavita R, Merlino F, Grieco P, Folliero V, De Filippis A, Mangoni M, Nencioni L, Franci G, Galdiero M. | Int J Mol Sci. 2022 Feb 13;23(4):2060. | DOI:10.3390/ijms23042060 | PMID:35216177 PMID35216177 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35216177/
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