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MYP_101025
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Basic Information
Beta-defensin 8 (BNBD-8) (BNDB-8)
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Standard
38 amino acids
C184H310N66O45S6
Standard
Sequence
VRNFVTCRINRGFCVPIRCPGHRRQIGTCLGPQIKCCR
Physicochemical Analysis
4359.23 Da
10.66
7.76
7.41
0.2042
-0.14
0.76
-0.18
38.52
74.21
0.0526
0.00
375.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1814.47
-20.38
71.0
60.0
141.0
301.0
6.0
41.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0285922 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
Defensin
9913;0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
PaperSelsted M.E., Tang Y.-Q., Morris W.L., McGuire P.A., Novotny M.J., Smith W., Henschen A.H., Cullor J.S.. "Purification, primary structures, and antibacterial activities of beta-defensins, a new family of antimicrobial peptides from bovine neutrophils."; J. Biol. Chem. 268:6641-6648. Evidence URLhttps://www.uniprot.org/uniprotkb/BD08_BOVIN/entry
RECORD: Rec_0286266 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
PaperAPD2: the updated antimicrobial peptide database and its application in peptide design PMID18957441 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18957441/
RECORD: Rec_0288972 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
Defensin
9913
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Escherichia coli
10-300 μg/mL
MIC
PMID8454635 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8454635/
RECORD: Rec_0290765 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
Defensin
9913
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
Escherichia coli ML35
PaperPurification, primary structures, and antibacterial activities of beta-defensins, a new family of antimicrobial peptides from bovine neutrophils.
RECORD: Rec_0358608 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
Beta-defensin; Defensin
9913
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
disulfide bond; sites not specified
Bio-Activity Profile
Antimicrobial Defensin Anti-Gram-negative Anti-Gram-positive Non-hemolytic
Escherichia coli
PMID8454635 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8454635/
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