Peptide Database

Peptide NameTBD-1 (Turtle beta-defensin 1; Reptiles, animals)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive ▸ Anti-Staphylococcus aureus

Antimicrobial ▸ Antibiotic activity

Antimicrobial ▸ Antifungal

Antimicrobial ▸ Antifungal ▸ Anti-Candida

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Standard StatusStandard

Sequence Length40 amino acids

Chemical FormulaC193H311N65O51S6

DescriptionStandard

        YDLSKNCRLRGGICYIGKCPRRFFRSGSCSRGNVCCLRFG
    

Molecular Weight4550.33 Da

Isoelectric Point (pI)9.86

Net Charge (pH 7.0)7.70

Net Charge (pH 7.4) 7.40

Charge Density (pH 7.0) 0.1924

GRAVY Index-0.29

Hydrophobic Moment 0.93

Boman Index-0.20

Instability Index63.07

Aliphatic Index 56.00

Aromaticity 0.1250

Extinction Coeff. Reduced 2980.00

Extinction Coeff. Oxidized 3355.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1919.63

LogP -23.01

H-bond Donors 78.0

H-bond Acceptors 65.0

Rotatable Bonds 151.0

Heavy Atoms 315.0

Ring Count 6.0

Amide Bonds 41.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0108711 VERIFIED: YES

Provenance & Taxonomy

OrganismEmys orbicularis [Plant]

FamilyDefensin

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Disulfide7-35, 14-29, 19-36

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal

TargetCandida albicans

Activity5.2 μM

MethodMIC

RECORD: Rec_0155061 VERIFIED: YES

Provenance & Taxonomy

OrganismEmys orbicularis [Plant]

FamilyDefensin

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Disulfide7-35, 14-29, 19-36

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Hemolytic

RECORD: Rec_0170496 VERIFIED: YES

Provenance & Taxonomy

OrganismEmys orbicularis [Animal]

FamilyDefensin

Structure & Mods

ConfigSingle-chain peptide backbone represented as a linear sequence entry [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative

Targetmethicillin-resistant Staphylococcus aureus

RECORD: Rec_0174848 VERIFIED: YES

Provenance & Taxonomy

OrganismEmys orbicularis [Plant]

FamilyDefensin

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Disulfide7-35, 14-29, 19-36

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal

Targethuman erythrocytes up to 25 mmol/L

Activity25000 μM

MethodHemolysis

RECORD: Rec_0238130 VERIFIED: YES

Provenance & Taxonomy

OrganismEmys orbicularis [Plant]

FamilyDefensin

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Disulfide7-35, 14-29, 19-36

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal

Targetmol/L sodium chloride

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