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MYP_100955
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Basic Information
TBD-1 (Turtle beta-defensin 1; Reptiles, animals)
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive ▸ Anti-Staphylococcus aureus
Antimicrobial ▸ Antibiotic activity
Antimicrobial ▸ Antifungal
Antimicrobial ▸ Antifungal ▸ Anti-Candida
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Standard
40 amino acids
C193H311N65O51S6
Standard
Sequence
YDLSKNCRLRGGICYIGKCPRRFFRSGSCSRGNVCCLRFG
Physicochemical Analysis
4550.33 Da
9.86
7.70
7.40
0.1924
-0.29
0.93
-0.20
63.07
56.00
0.1250
2980.00
3355.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1919.63
-23.01
78.0
65.0
151.0
315.0
6.0
41.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0001699 VERIFIED: YES
Provenance & Taxonomy
Emys orbicularis [Plant]
Defensin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
7-35, 14-29, 19-36
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
NOTE: LS (low salt): 10 mmol/L sodium phosphate buffer (pH 7.4) and HS (high salt): 10 mmol/L sodium-phosphate buffer (pH 7.4)
PMID19253295 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19253295/
RECORD: Rec_0002215 VERIFIED: YES
Provenance & Taxonomy
Emys orbicularis [Plant]
Defensin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
7-35, 14-29, 19-36
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
(LS, HS): Listeria monocytogenes EGD
0.65 μM
MIC
PMID19253295 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19253295/
RECORD: Rec_0009404 VERIFIED: YES
Provenance & Taxonomy
Emys orbicularis [Plant]
Defensin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
7-35, 14-29, 19-36
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
PMID19253295 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19253295/
RECORD: Rec_0038189 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct based on European pond turtle [Synthetic]
Defensin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal
PaperIsolation, purification and de novo sequencing of TBD-1, the first beta-defensin from leukocytes of reptiles.
RECORD: Rec_0038694 VERIFIED: YES
Provenance & Taxonomy
Emys orbicularis [Animal]
Defensin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Candida albicans
5.2 μM
MIC
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