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MYP_100894
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Basic Information
Cationic Amphiphilic
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
16 amino acids
C92H176N22O17
Standard
Sequence
GIIKKIIIKKIIIKKI
Physicochemical Analysis
1862.52 Da
10.70
5.75
5.54
0.3596
1.04
0.28
0.24
-27.77
219.38
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
655.94
1.49
23.0
23.0
73.0
131.0
0.0
15.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0275552 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
cyclic peptide; DSSP H 25.0%, E 0.0%, T 43.8%, C 31.2% [Cyclic]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Anticancer Antimicrobial
PaperCancerPPD: a database of anticancer peptides and proteins PMID25270878 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25270878/
RECORD: Rec_0277117 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Cationic amphiphilic peptides
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Anticancer
HL-60 (blood cancer)
25 μM
IC50
PaperDesigned antimicrobial and antitumor peptides with high selectivity | https://pubmed.ncbi.nlm.nih.gov/21955251/ PMID21955251 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21955251/
RECORD: Rec_0294729 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
AMP
Structure & Mods
cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Anticancer Cytotoxic
HeLa
15 μM
IC50
PMID21955251 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21955251/
RECORD: Rec_0309863 VERIFIED: YES
Provenance & Taxonomy
AMP [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Anticancer
HL-60
25 μM
IC50
PaperPubMed PMID: 21955251 PMID21955251 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21955251/
RECORD: Rec_0339941 VERIFIED: YES
Provenance & Taxonomy
AMP [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Anticancer Hemolytic
bacteria and cancer cells, there is little activity or toxicity against hRBCs
PaperPubMed PMID: 21955251 PMID21955251 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21955251/
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