Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length240 amino acids

Chemical FormulaC1242H1905N307O331S13

DescriptionStandard

        MLPWEPAHGPSSFSLVMTKIDAVAGINYGLVAPPTTTAETLDVQMKGEFYSQNHHNPPPFAPPVMEFPAAHDRMVYLGLSDYFFNTAGLVYQEAGVLKMTLRDDMIPKESKFRLTTKFFGNFLPEVAKRFPNMKIQIHVSASTPPHLSVQPTGLTFYPAVDVQAFAVLPNSSLASLFLIGMVELLQDIMNYMVPILVLPRVNEKLQKGFPLPMPARVQLYNMVLQPHHNFLLFGADVVYK
    

Molecular Weight26850.11 Da

Isoelectric Point (pI)6.70

Net Charge (pH 7.0)-0.79

Net Charge (pH 7.4) -1.46

Charge Density (pH 7.0) -0.0033

GRAVY Index0.12

Hydrophobic Moment 0.66

Boman Index0.19

Instability Index44.24

Aliphatic Index 90.96

Aromaticity 0.1125

Extinction Coeff. Reduced 18910.00

Extinction Coeff. Oxidized 18910.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0242050 VERIFIED: NO

Provenance & Taxonomy

OrganismNomascus leucogenys [Bacterium]

FamilyBPI

Tax ID61853

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence