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MYP_100819
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Basic Information
Adrenomedullin
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Cardiovascular
Cardiovascular ▸ Vascular tone modulation ▸ Vasoactive peptide
Cardiovascular ▸ Vascular tone modulation ▸ Vasoconstrictor activity
Cardiovascular ▸ Vascular tone modulation ▸ Vasodilatory activity
Hormonal / Endocrine ▸ Hormone peptide
Immunology ▸ Immune modulation ▸ Immunomodulatory activity
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Neurological / Signaling ▸ Neuromuscular and muscle activity ▸ Myotropic activity
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide
Regulatory peptide ▸ Biological modulation
Regulatory peptide ▸ Biological regulation
Reproductive biology ▸ Reproductive modulation
Wound healing/Regeneration ▸ Angiogenesis modulation ▸ Angiogenic
Standard
52 amino acids
C264H407N79O78S3
Standard
Sequence
YRQSMNNFQGLRSFGCRFGTCTVQKLAHQIYQFTDKDKDNVAPRSKISPQGY
Physicochemical Analysis
6031.73 Da
9.70
4.82
4.53
0.0928
-0.89
0.64
-0.20
44.22
45.00
0.1346
4470.00
4595.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
2612.21
-31.08
92.0
87.0
201.0
424.0
10.0
60.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0035042 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
16-21
Bio-Activity Profile
Antimicrobial
P. acnes and P. gingivalis ATCC 33277
0.003 μg/mL
MBC
PaperAn investigation into the antimicrobial effects of adrenomedullin on members of the skin, oral, respiratory tract and gut microflora
RECORD: Rec_0135745 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
adrenomedullin family
9606; 0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
16-21
Bio-Activity Profile
Hormone adrenomedullin family Antibacterial Angiogenic Host defense
PaperPDB 4RWF structural record; X-ray; 1.76 A; chain B; residues 25-52
RECORD: Rec_0167316 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
9606
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
PEGylation
Amidation
16-21
Bio-Activity Profile
Vasodilator
0.00944±0.0003 μM
ELISA
Male Wistar rats plasma, in vivo; 6480 s
PMID24874704 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24874704/
RECORD: Rec_0181657 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Adrenomedullin
9606
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Amidation
16-21
Bio-Activity Profile
Antimicrobial Anti-Gram-negative Hormone Endocrine Vasoactive Vasoconstrictor Cardiovascular Reproductive regulator Growth regulation Development regulation Myotropic Receptor modulation Immunomodulatory
promotes proliferation and migration of vascular endothelial cells
Experimental: 0.62±0.02 (1st plasma half life) minutes; /37.2 seconds; Mammalian: 2.8 hour; Yeast: 10 min; E. coli: 2 min
PaperSource-linked PubMed record(s) for Adrenomedullin (Homo sapiens): PMID 24874704 PMID24874704 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24874704/
RECORD: Rec_0210094 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
PMID10225288 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10225288/
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