Peptide Database

Peptide NameOmalizumab

Function Ontology

Immunology ▸ Immune modulation ▸ Immunomodulatory activity

Standard StatusStandard

Sequence Length242 amino acids

Chemical FormulaC1145H1748N304O353S8

DescriptionStandard

        EVQLVESGGGLVQPGGSLRLSCAVSGYSITSGYSWNWIRQAPGKGLEWVASITYDGSTNYADSVKGRFTISRDDSKNTFYLQMNSLRAEDTAVYYCARGSHYFGHWHFAVWGQGTLVTVSSGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKAEPKSCDKTHTCPPCPAPELLGGPSVFL
    

Molecular Weight25676.47 Da

Isoelectric Point (pI)8.19

Net Charge (pH 7.0)2.29

Net Charge (pH 7.4) 1.67

Charge Density (pH 7.0) 0.0095

GRAVY Index-0.14

Hydrophobic Moment 0.46

Boman Index0.12

Instability Index47.21

Aliphatic Index 71.24

Aromaticity 0.1033

Extinction Coeff. Reduced 49390.00

Extinction Coeff. Oxidized 49765.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0394443 VERIFIED: YES

Provenance & Taxonomy

OrganismHomo sapiens [Animal]; Cricetulus griseus [Animal]

FamilyMonoclonal antibody

Tax ID9606;10029

Structure & Mods

Configlinear multidomain protein biologic [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Immunomodulatory Anti-allergic Anti-IgE

Half-Life624 h

PaperPubMed-linked source references: PMID:27426720; PMID:16810345; PMID:16179960; PMID:28319473; PMID:28314658; PMID:28303277; PMID:28303134; PMID:28302544; PMID:28295198 PMID27426720;16810345;16179960;28319473;28314658;28303277;28303134;28302544;28295198 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27426720/ PatentCA1340233