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MYP_100722
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Basic Information
Unnamed
Antimicrobial
Antiviral
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition
Enzyme modulation ▸ Enzyme inhibition ▸ Reverse transcriptase inhibition
Standard
17 amino acids
C75H128N18O29S
Standard
Sequence
GTKALTEVIALTEEAEC
Physicochemical Analysis
1777.99 Da
4.09
-3.24
-3.47
-0.1906
0.22
0.40
0.15
72.10
103.53
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
764.83
-7.70
27.0
27.0
60.0
123.0
0.0
16.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0039943 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Antimicrobial
PaperHIPdb: a database of experimentally validated HIV inhibiting peptides PMID23359817 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23359817/
RECORD: Rec_0146386 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-HIV-1 Replication inhibition
HIV-1
7±1.4 μM
KI
Mammalian: 30 h; Yeast: >20 h; E. coli: >10 h
PaperA new generation of peptide-based inhibitors targeting HIV-1 reverse transcriptase conformational flexibility. | Agopian A, Gros E, Aldrian-Herrada G, Bosquet N, Clayette P, Divita G. | J Biol Chem. 2009 Jan 2;284(1):254-264. | DOI:10.1074/jbc.M802199200 | PMID:18952602 PMID18952602 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18952602/
RECORD: Rec_0181122 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
HIV-1:inhibition of polymerase activity of HIV-1 RT(Ki =7 ± 1.4 μM)
PaperA New Generation of Peptide-based Inhibitors Targeting HIV-1 Reverse Transcriptase Conformational Flexibility PMID18952602 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18952602/
RECORD: Rec_0324066 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Reverse transcriptase inhibition
HeLa
7±1.4 μM
Ki
PaperA new generation of peptide-based inhibitors targeting HIV-1 reverse transcriptase conformational flexibility. PMID18952602 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18952602/
RECORD: Rec_0349575 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
PaperA New Generation of Peptide-based Inhibitors Targeting HIV-1 Reverse Transcriptase Conformational Flexibility PMID18952602 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18952602/