Peptide Database

Peptide NameSLAY-screened peptide P1708

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length21 amino acids

Chemical FormulaC104H178N26O31

DescriptionStandard

        SLWLRLSSSISLIVTALTLTN
    

Molecular Weight2288.68 Da

Isoelectric Point (pI)9.47

Net Charge (pH 7.0)0.46

Net Charge (pH 7.4) 0.25

Charge Density (pH 7.0) 0.0219

GRAVY Index1.09

Hydrophobic Moment 0.45

Boman Index0.35

Instability Index38.95

Aliphatic Index 167.14

Aromaticity 0.0476

Extinction Coeff. Reduced 5500.00

Extinction Coeff. Oxidized 5500.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 927.94

LogP -8.89

H-bond Donors 35.0

H-bond Acceptors 32.0

Rotatable Bonds 74.0

Heavy Atoms 161.0

Ring Count 2.0

Amide Bonds 21.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0172247 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/