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MYP_100640
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Basic Information
Cliotide T19
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
30 amino acids
C130H221N37O41S6
Standard
Sequence
GSVIKCGESCLLGKCYTPGCTCSRPICKKD
Physicochemical Analysis
3150.76 Da
8.65
2.70
2.40
0.0901
-0.04
0.51
-0.02
46.08
61.67
0.0333
1490.00
1865.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1251.60
-15.78
50.0
50.0
104.0
214.0
3.0
29.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0241835 VERIFIED: YES
Provenance & Taxonomy
Clitoria ternatea [Plant]
Structure & Mods
side-chain cyclized/stapled peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anticancer Hemolytic
PMID23419988 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23419988/
RECORD: Rec_0266547 VERIFIED: YES
Provenance & Taxonomy
Clitoria ternatea [Plant]
Structure & Mods
side-chain cyclized/stapled peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anticancer
A549
9.59 μM
IC50
PMID23419988 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23419988/
RECORD: Rec_0276696 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anticancer
PaperAPD2: the updated antimicrobial peptide database and its application in peptide design PMID18957441 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18957441/
RECORD: Rec_0282945 VERIFIED: YES
Provenance & Taxonomy
Clitoria ternatea [Plant]
43366
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Anticancer
Human non-small lung cancer cells A549 and Escherichia coli
0.6 μM
MIC
PaperLett. 2013 Feb;5(2):641-644. Epub 2012 Nov 22. Chemosensitizing activities of cyclotides from Clitoria ternatea in paclitaxel-resistant lung cancer cells.
RECORD: Rec_0370057 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Anticancer
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