Peptide Database

Peptide NameM0

Function Ontology

Antimicrobial

Antiviral

Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition

Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor

Standard StatusStandard

Sequence Length30 amino acids

Chemical FormulaC157H259N35O51S

DescriptionStandard

        TTLLDLTYEMLSLQQVVKALNESYIDLKEL
    

Molecular Weight3485.00 Da

Isoelectric Point (pI)4.18

Net Charge (pH 7.0)-3.60

Net Charge (pH 7.4) -3.80

Charge Density (pH 7.0) -0.1198

GRAVY Index0.16

Hydrophobic Moment 0.61

Boman Index0.13

Instability Index24.56

Aliphatic Index 139.67

Aromaticity 0.0667

Extinction Coeff. Reduced 2980.00

Extinction Coeff. Oxidized 2980.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1416.64

LogP -9.81

H-bond Donors 48.0

H-bond Acceptors 49.0

Rotatable Bonds 120.0

Heavy Atoms 244.0

Ring Count 2.0

Amide Bonds 32.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0295621 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyFusion-inhibitory peptide

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antiviral Fusion inhibition

Targetinhibition of pseudovirus infection in MT-2 cells

Activity17.8 μM

MethodIC50

Half-LifeMammalian: 7.2 h; Yeast: >20 h; E. coli: >10 h

PaperCreating an Artificial Tail Anchor as a Novel Strategy To Enhance the Potency of Peptide-Based HIV Fusion Inhibitors. | Su S, Zhu Y, Ye S, Qi Q, Xia S, Ma Z, Yu F, Wang Q, Zhang R, Jiang S, Lu L. | J Virol. 2016 Dec 16;91(1):e01445-16. | DOI:10.1128/JVI.01445-16 | PMID:27795416 PMID27795416 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27795416/

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