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MYP_100507
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Basic Information
Lfc9
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Standard
13 amino acids
C76H123N27O15S3
Standard
Sequence
CRRWQWRMKKLGC
Physicochemical Analysis
1751.16 Da
10.93
4.74
4.50
0.3645
-1.25
0.57
-0.54
90.82
30.00
0.1538
11000.00
11125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
724.93
-4.73
30.0
23.0
59.0
121.0
4.0
13.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0003338 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Lactoferricin
32630
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Amidation
1-13
Bio-Activity Profile
Antimicrobial Antibacterial
Staphylococcus aureus
≤0.45 μM
LD99
Human Serum: Have half-lifes of ~1.5 h
PaperNguyen LT, Chau JK, Perry NA, de Boer L, Zaat SA, Vogel HJ. Serum stabilities of short tryptophan- and arginine-rich antimicrobial peptide analogs. PLoS One. 2010 Sep 10;5(9):e12684. PMID:20844765 https://pubmed.ncbi.nlm.nih.gov/20844765/ PMID20844765 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20844765/
RECORD: Rec_0005128 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Lactoferricin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
1-13
Bio-Activity Profile
Antimicrobial
amd Staphylococcus aureus
25-50 μg/mL
MIC
PaperStructural studies and model membrane interactions of two peptides derived from bovine lactoferricin.
RECORD: Rec_0041334 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Hemolytic
human red blood cells
Hemolysis
PMID20844765 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20844765/
RECORD: Rec_0105576 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Amidation
1-13
Bio-Activity Profile
Antimicrobial Anti-Gram-negative
Escherichia coli
1.9 μM
LD99.99
Human serum, in vitro; 6600 s
PaperSerum stabilities of short tryptophan- and arginine-rich antimicrobial peptide analogs PMID20844765 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20844765/
RECORD: Rec_0164105 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
Staphylococcus aureus 42D LC
<0.45 μM
PMID20844765 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20844765/
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