Peptide Database

Peptide NameBactericidal permeability-increasing protein

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length482 amino acids

Chemical FormulaC2406H3730N630O689S24

DescriptionStandard

        MFLSVTAVLMLFSCAHGENPAIQVILTNKGLQYGKHAGTDWIQKMLEHVTLPDISGKVNVGFWCSIHYTLTNTSIEKCDLPEPSADFYPDATGLKTSMSGLSVALSGQWMTHFGIIHDKGSFDMAILGVDVTSVVELGKDADGHLSVSSANCVAQVGDVDVRFHGGASWIFKRFVKHFKKRISKEIENRICPNVEELIASVEYHLQAMNVSFEVDPAMAMNLSLSTSPTIDVSSLNLGLKGEFFSEKTRADPPFEAQPFTMPEQQAFMLSWGLSEFTLNSASYVYYSYGVFQRFIDDSMIPPGFPLHLNTSLMGPYVPQLPKMFPGLLMDLHVYARDTPMFSFQPGAVKLGIQGAVKAFAIQPNGTQTPLFQLNIVSGCSSPSRQYKQKETRARIRPSTFTSCAASSCLVFGVRDTKLKVHHVPFVVDLQFIVSERLGRGLVLPRLKRAQLVNSVLKVQEGFIALFSDADVFLTDRGFNQQN
    

Molecular Weight53274.72 Da

Isoelectric Point (pI)6.70

Net Charge (pH 7.0)-1.31

Net Charge (pH 7.4) -2.45

Charge Density (pH 7.0) -0.0027

GRAVY Index0.03

Hydrophobic Moment 0.91

Boman Index0.12

Instability Index33.25

Aliphatic Index 86.93

Aromaticity 0.1017

Extinction Coeff. Reduced 43890.00

Extinction Coeff. Oxidized 44390.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0066345 VERIFIED: NO

Provenance & Taxonomy

OrganismScophthalmus maximus [Animal]

FamilyBPI/LBP

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic Non-ribosomal

TargetGram-negative bacteria

MethodQualitative functional evidence