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MYP_100427
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Basic Information
BMAP-18X6X10
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antiviral
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
not Standard
18 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
GRFKRXRKKXKKLFKKIS
Physicochemical Analysis
0.00 Da
0.00
0.00
0.00
0.00
0.00
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0318826 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
The 'X' at position 6 and 10 are phenylglycine
Bio-Activity Profile
Antimicrobial Antiviral
(EC50:50% effective concentration for inhibition of virus replication)
PaperAnti-human immunodeficiency virus type 1 activities of antimicrobial peptides derived from human and bovine cathelicidins. Antimicrob Agents Chemother. 2008 Sep;52(9):3438-3440. doi: 10.1128/AAC.00452-08. PMID: 18591279. PMID18591279 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18591279/
RECORD: Rec_0331350 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Cathelicidin
32630
Structure & Mods
synthetic linear peptide [Linear]
stereochemistry not specified [Other]
None
None
The 'X' at position 6 and 10 are phenylglycine
Bio-Activity Profile
Antiviral Anti-HIV-1 Entry inhibition
HIV-1IIIB | CEM-SS cells
0.68 μM
EC50
Mammalian: 30 h; Yeast: >20 h; E. coli: >10 h
PaperAnti-human immunodeficiency virus type 1 activities of antimicrobial peptides derived from human and bovine cathelicidins. | Wang G, Watson KM, Buckheit RW Jr. | Antimicrob Agents Chemother. 2008 Sep;52(9):3438-40. | DOI:10.1128/AAC.00452-08 | PMID:18591279 PMID18591279 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18591279/
RECORD: Rec_0378411 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
cathelicidin
32630
Structure & Mods
synthetic linear peptide [Linear]
noncanonical stereochemical modification [Modified]
unspecified non-canonical residue at 6,10
Bio-Activity Profile
Hemolytic
CEM-SS cells 50% cell death at 10.2 microM
10.2 μM
Hemolysis
PMID18591279 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18591279/
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