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MYP_100414
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Basic Information
P23(derived from HCV polyprotein)
Antimicrobial
Antiviral
Antiviral ▸ Anti-Hepatitis virus ▸ Anti-HCV
Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition
Enzyme modulation ▸ Enzyme inhibition ▸ Protease inhibition
Standard
14 amino acids
C63H98N14O25
Standard
Sequence
ADLEVVAATYVDDA
Physicochemical Analysis
1451.53 Da
4.05
-4.20
-4.39
-0.2999
0.54
0.21
0.25
-7.51
118.57
0.0714
1490.00
1490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
631.28
-5.59
21.0
21.0
44.0
102.0
1.0
13.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0101981 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-HCV Replication inhibition
Hepatitis C virus (HCV)
3 μM
% inhibition
Mammalian: 4.4 h; Yeast: >20 h; E. coli: >10 h
PaperPeptide inhibitors of hepatitis C virus NS3 protease. | Portal-Núñez S, González-Navarro CJ, García-Delgado M, Vizmanos JL, Lasarte JJ, Borrás-Cuesta F. | Antivir Chem Chemother. 2003 Sep;14(5):225-33. | DOI:10.1177/095632020301400501 | PMID:14694985 PMID14694985 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/14694985/
RECORD: Rec_0216800 VERIFIED: YES
Provenance & Taxonomy
Hepatitis C virus [Virus]
Virus-derived peptide
3052230;0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Protease inhibitor
Hepatitis C virus (NS3 protease); BL21(DE3)
20 %
Fluorescent probe
PaperPeptide inhibitors of hepatitis C virus NS3 protease. | Portal-Nunez S, Gonzalez-Navarro CJ, Garcia-Delgado M, Vizmanos JL, Lasarte JJ, Borras-Cuesta F. | Antivir Chem Chemother. 2003 | PMID:14694985 PMID14694985 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/14694985/
RECORD: Rec_0239610 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
PaperPeptide inhibitors of hepatitis C virus NS3 protease. Antivir Chem Chemother. 2003 Sep;14(5):225-33. doi: 10.1177/095632020301400501. PMID: 14694985. PMID14694985 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/14694985/
RECORD: Rec_0266061 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
Hepatitis C virus(HCV):inhibition of activation of NS3-6K protease
20 %
Inhibition
PaperPeptide inhibitors of hepatitis C virus NS3 protease. Antivir Chem Chemother. 2003 Sep;14(5):225-33. doi: 10.1177/095632020301400501. PMID: 14694985. PMID14694985 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/14694985/
RECORD: Rec_0418625 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 21.4%, E 0.0%, T 28.6%, C 50.0% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Antimicrobial
PaperAVPdb: a database of experimentally validated antiviral peptides targeting medically important viruses PMID24285301 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24285301/