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MYP_100380
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Basic Information
Unnamed
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
28 amino acids
C124H222N34O37S3
Standard
Sequence
GIMDSVKGLAKNLAGKLLDSLKCKITGC
Physicochemical Analysis
2877.49 Da
9.24
2.74
2.50
0.0978
0.31
0.58
0.11
1.15
115.00
0.0000
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1157.50
-11.52
42.0
43.0
104.0
198.0
0.0
28.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0267558 VERIFIED: YES
Provenance & Taxonomy
Rana boylii [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
23-28
Bio-Activity Profile
Antimicrobial Antifungal
Escherichia coli
17 μM
MIC
PaperIsolation of peptides of the brevinin-1 family with potent candidacidal activity from the skin secretions of the frog Rana boylii
RECORD: Rec_0275354 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0339029 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antibacterial
Human erythrocytes
200 μM
HC50
Paperhttps://pubmed.ncbi.nlm.nih.gov/14531844/ PMID14531844 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/14531844/
RECORD: Rec_0341806 VERIFIED: YES
Provenance & Taxonomy
Rana boylii [Animal]
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
23-28
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
Escherichia coli
17 μM
MIC
RECORD: Rec_0402055 VERIFIED: YES
Provenance & Taxonomy
American frog [Animal]
Brevinin
33208
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
23-28
Bio-Activity Profile
Antimicrobial
PMID14531844 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/14531844/
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