Peptide Database

Peptide NameAc-DS-3W

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Standard StatusStandard

Sequence Length15 amino acids

Chemical FormulaC71H124N22O16

DescriptionStandard

        KAAKWAKKAAKAAAK
    

Molecular Weight1541.88 Da

Isoelectric Point (pI)10.70

Net Charge (pH 7.0)5.75

Net Charge (pH 7.4) 5.54

Charge Density (pH 7.0) 0.3836

GRAVY Index-0.66

Hydrophobic Moment 0.71

Boman Index-0.22

Instability Index-0.69

Aliphatic Index 53.33

Aromaticity 0.0667

Extinction Coeff. Reduced 5500.00

Extinction Coeff. Oxidized 5500.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 642.63

LogP -5.16

H-bond Donors 23.0

H-bond Acceptors 22.0

Rotatable Bonds 55.0

Heavy Atoms 109.0

Ring Count 2.0

Amide Bonds 14.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0402054 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Confighydrocarbon-stapled side-chain cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermAcetylation

C-TermAmidation

Other ModsThe Ⓧ (position: 2 ,6, 9 and 13) in sequence indicates (S)-α-methyl, α-pentenylglycine. Ⓧ (2) and Ⓧ (6), Ⓧ (9) and Ⓧ (13) are cross-linked by hydrocarbon stapling through an oct-4-enyl hydrocarbon staple

Bio-Activity Profile

Function

Antimicrobial Antibacterial

TargetSalmonella typhimurium ATCC 14028

Activity100 μM

MethodMIC

RECORD: Rec_0405703 VERIFIED: YES