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MYP_100263
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Basic Information
Ac-DS-3W
Antimicrobial
Antimicrobial ▸ Antibacterial
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Standard
15 amino acids
C71H124N22O16
Standard
Sequence
KAAKWAKKAAKAAAK
Physicochemical Analysis
1541.88 Da
10.70
5.75
5.54
0.3836
-0.66
0.71
-0.22
-0.69
53.33
0.0667
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
642.63
-5.16
23.0
22.0
55.0
109.0
2.0
14.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0247346 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
The Ⓧ (position: 2 ,6, 9 and 13) in sequence indicates (S)-α-methyl, α-pentenylglycine. Ⓧ (2) and Ⓧ (6), Ⓧ (9) and Ⓧ (13) are cross-linked by hydrocarbon stapling through an oct-4-enyl hydrocarbon staple
Bio-Activity Profile
Hemolytic
human red blood cells
12.5 μM
Hemolysis
PaperThuy T T Dinh, Do-Hee Kim, Huy X Luong, Bong-Jin Lee, Young-Woo Kim. Antimicrobial activity of doubly-stapled alanine/lysine-based peptides. Bioorg Med Chem Lett. 2015 Sep 15;25(18):4016-9. Epub 2015 Jun 19. PMID26235946 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26235946/
RECORD: Rec_0249095 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Succinylation
Amidation
The Ⓧ (position: 2 ,6, 9 and 13) in sequence indicates (S)-α-methyl, α-pentenylglycine. Ⓧ (2) and Ⓧ (6), Ⓧ (9) and Ⓧ (13) are cross-linked by hydrocarbon stapling through an oct-4-enyl hydrocarbon staple
Bio-Activity Profile
Antimicrobial Antibacterial
Shigella dysenteriae ATCC 9752
50 μM
MIC
PaperThuy T T Dinh, Do-Hee Kim, Huy X Luong, Bong-Jin Lee, Young-Woo Kim. Antimicrobial activity of doubly-stapled alanine/lysine-based peptides. Bioorg Med Chem Lett. 2015 Sep 15;25(18):4016-9. Epub 2015 Jun 19. PMID26235946 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26235946/
RECORD: Rec_0268537 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Amidation
The Ⓧ (position: 2 ,6, 9 and 13) in sequence indicates (S)-α-methyl, α-pentenylglycine. Ⓧ (2) and Ⓧ (6), Ⓧ (9) and Ⓧ (13) are cross-linked by hydrocarbon stapling through an oct-4-enyl hydrocarbon staple
Bio-Activity Profile
Antimicrobial Antibacterial
Escherichia coli ATCC 25922
3.1 μM
MIC
PaperThuy T T Dinh, Do-Hee Kim, Huy X Luong, Bong-Jin Lee, Young-Woo Kim. Antimicrobial activity of doubly-stapled alanine/lysine-based peptides. Bioorg Med Chem Lett. 2015 Sep 15;25(18):4016-9. Epub 2015 Jun 19. PMID26235946 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26235946/
RECORD: Rec_0288632 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Amidation
The Ⓧ (position: 2 ,6, 9 and 13) in sequence indicates (S)-α-methyl, α-pentenylglycine. Ⓧ (2) and Ⓧ (6), Ⓧ (9) and Ⓧ (13) are cross-linked by hydrocarbon stapling through an oct-4-enyl hydrocarbon staple
Bio-Activity Profile
Antimicrobial Antibacterial
Staphylococcus aureus ATCC 6538p
1.6 μM
MIC
PaperThuy T T Dinh, Do-Hee Kim, Huy X Luong, Bong-Jin Lee, Young-Woo Kim. Antimicrobial activity of doubly-stapled alanine/lysine-based peptides. Bioorg Med Chem Lett. 2015 Sep 15;25(18):4016-9. Epub 2015 Jun 19. PMID26235946 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26235946/
RECORD: Rec_0320939 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Amidation
The Ⓧ (position: 2 ,6, 9 and 13) in sequence indicates (S)-α-methyl, α-pentenylglycine. Ⓧ (2) and Ⓧ (6), Ⓧ (9) and Ⓧ (13) are cross-linked by hydrocarbon stapling through an oct-4-enyl hydrocarbon staple
Bio-Activity Profile
Antimicrobial Antibacterial
Pseudomonas aeruginosa ATCC 27853
6.3 μM
MIC
PaperThuy T T Dinh, Do-Hee Kim, Huy X Luong, Bong-Jin Lee, Young-Woo Kim. Antimicrobial activity of doubly-stapled alanine/lysine-based peptides. Bioorg Med Chem Lett. 2015 Sep 15;25(18):4016-9. Epub 2015 Jun 19. PMID26235946 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26235946/
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