MYP_100263
Ac-DS-3W
Antimicrobial
Antimicrobial
▸
Antibacterial
Toxicity / Safety
▸
Blood cell toxicity
▸
Hemolysis
▸
Hemolytic
Standard
15 amino acids
C71H124N22O16
Standard
KAAKWAKKAAKAAAK
1541.88 Da
10.70
5.75
5.54
0.3836
-0.66
0.71
-0.22
-0.69
53.33
0.0667
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Amino Acid Composition
642.63
-5.16
23.0
22.0
55.0
109.0
2.0
14.0
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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RECORD: Rec_0020589
VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
The Ⓧ (position: 2 ,6, 9 and 13) in sequence indicates (S)-α-methyl, α-pentenylglycine. Ⓧ (2) and Ⓧ (6), Ⓧ (9) and Ⓧ (13) are cross-linked by hydrocarbon stapling through an oct-4-enyl hydrocarbon staple
Bio-Activity Profile
Antimicrobial
Antibacterial
Pseudomonas aeruginosa ATCC 27853
200 μM
MIC
RECORD: Rec_0023213
VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Succinylation
Amidation
The Ⓧ (position: 2 ,6, 9 and 13) in sequence indicates (S)-α-methyl, α-pentenylglycine. Ⓧ (2) and Ⓧ (6), Ⓧ (9) and Ⓧ (13) are cross-linked by hydrocarbon stapling through an oct-4-enyl hydrocarbon staple
Bio-Activity Profile
Hemolytic
human red blood cells
12.5 μM
Hemolysis
RECORD: Rec_0024539
VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Succinylation
Amidation
The Ⓧ (position: 2 ,6, 9 and 13) in sequence indicates (S)-α-methyl, α-pentenylglycine. Ⓧ (2) and Ⓧ (6), Ⓧ (9) and Ⓧ (13) are cross-linked by hydrocarbon stapling through an oct-4-enyl hydrocarbon staple
Bio-Activity Profile
Antimicrobial
Antibacterial
Bacillus subtilis ATCC 6633
1.6 μM
MIC
RECORD: Rec_0041862
VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
The Ⓧ (position: 2 ,6, 9 and 13) in sequence indicates (S)-α-methyl, α-pentenylglycine. Ⓧ (2) and Ⓧ (6), Ⓧ (9) and Ⓧ (13) are cross-linked by hydrocarbon stapling through an oct-4-enyl hydrocarbon staple
Bio-Activity Profile
Antimicrobial
Antibacterial
Klebsiella pneumoniae ATCC 10031
100 μM
MIC
RECORD: Rec_0057102
VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Succinylation
Amidation
The Ⓧ (position: 2 ,6, 9 and 13) in sequence indicates (S)-α-methyl, α-pentenylglycine. Ⓧ (2) and Ⓧ (6), Ⓧ (9) and Ⓧ (13) are cross-linked by hydrocarbon stapling through an oct-4-enyl hydrocarbon staple
Bio-Activity Profile
Antimicrobial
Antibacterial
Staphylococcus aureus ATCC 6538p
1.6 μM
MIC
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