Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length114 amino acids

Chemical FormulaC553H881N145O167S3

DescriptionStandard

        PDLSGYEKFGLGNVKYNISRIHITAVEFPSASISLIPGTGIKLVIGNASLTIDMNWNIRTWMFKDSGRSTVYISKVFVTAIFSTPLDNTGHTSIALTSCRTTSGDIDIKLSGKS
    

Molecular Weight12328.98 Da

Isoelectric Point (pI)9.24

Net Charge (pH 7.0)3.13

Net Charge (pH 7.4) 2.93

Charge Density (pH 7.0) 0.0274

GRAVY Index0.09

Hydrophobic Moment 0.53

Boman Index0.14

Instability Index21.32

Aliphatic Index 94.91

Aromaticity 0.0877

Extinction Coeff. Reduced 15470.00

Extinction Coeff. Oxidized 15470.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 4993.78

LogP -54.40

H-bond Donors 180.0

H-bond Acceptors 175.0

Rotatable Bonds 406.0

Heavy Atoms 868.0

Ring Count 18.0

Amide Bonds 119.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0114096 VERIFIED: NO

Provenance & Taxonomy

OrganismSpizaetus tyrannus [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria