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MYP_100014
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Basic Information
Pep1
Anticancer
Anticancer ▸ Anti-breast cancer
Anticancer ▸ Apoptosis induction
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antiviral
Antiviral ▸ Anti-Herpesvirus ▸ Anti-HSV ▸ Anti-HSV-1
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Wound healing/Regeneration ▸ Angiogenesis modulation ▸ Anti-angiogenic
Standard
22 amino acids
C123H200N40O26S3
Standard
Sequence
FKCRRWQWRMKKLGAPSITCVR
Physicochemical Analysis
2751.35 Da
11.57
6.74
6.50
0.3062
-0.66
0.57
-0.32
61.15
53.18
0.1364
11000.00
11125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1106.42
-8.13
44.0
36.0
91.0
192.0
6.0
22.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0222706 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
9913
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anticancer
PMID18425992 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18425992/
RECORD: Rec_0277371 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
Lactoferrin-derived peptide
9913
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Anticancer Cytotoxic
HL-60
77 μM
IC50
PMID18425992 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18425992/
RECORD: Rec_0282466 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
Lactoferricin
9913
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anticancer Cytotoxic Anti-HSV-1 Antiviral Anti-breast cancer Pro-apoptotic
Herpes simplex virus 1
PaperLactoferricin-induced apoptosis in estrogen-nonresponsive MDA-MB-435 breast cancer cells is enhanced by C6 ceramide or tamoxifen | Furlong, S. et al. | DOI: 10.3892/or.15.5.1385 Evidence URLhttps://www.uniprot.org/uniprotkb/P24627/entry
RECORD: Rec_0301670 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
Lactoferricin
9913
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anticancer Cytotoxic Anti-HSV-1 Antiviral Pro-apoptotic
Herpes simplex virus 1
PaperBovine lactoferricin causes apoptosis in Jurkat T-leukemia cells by sequential permeabilization of the cell membrane and targeting of mitochondria | Mader, J. et al. | DOI: 10.1016/j.yexcr.2007.05.015 Evidence URLhttps://www.uniprot.org/uniprotkb/P24627/entry
RECORD: Rec_0301771 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
Lactoferricin
9913
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anticancer Cytotoxic Anti-HSV-1 Antiviral
Herpes simplex virus 1
PaperThe antimicrobial peptide, lactoferricin B, is cytotoxic to neuroblastoma cells in vitro and inhibits xenograft growth in vivo | Eliassen, Liv. et al. | DOI: 10.1002/ijc.21886 Evidence URLhttps://www.uniprot.org/uniprotkb/P24627/entry
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