Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length493 amino acids

Chemical FormulaC2465H3840N628O676S18

DescriptionStandard

        MLWLLVVLLGVGTEAVTPGIKTKITLKGLDYGKQVGMEFLKLALLQLPIPDFRGSYSVPLVGQVEYAVTGFQVNTINLGESLVAFAPSSRIKLSMGSAEAQVNGHWSVKVSLIHDNGTLKLHVGDMMLAVLIEVGWDGTGRLVVSPAGCSCHIGHLDVTFYGGASWLYNIFTGALEHVLRQELGNKLCKEIQNAVEALEQTLQTIPESSHISSLADLDYSLVAPPLITEQSIELNLKGEFYSRAGHKEAPVPPAPFSFWEQNDRMLLLGVSDFVANSAAFVYYGAGALSWNLTDSTVPKKFPIHINTKIFKGLVPELLKRFPDTPMALQIFARLPPWLQTQPGTLQLLLPGAVQAFILPNGTSPVPVFLLHVDIEASAQVFISGKNIGASLKLTNVSLTLAHSDVGPFPVDRIETLLYVALKAAILPRINRIFGHCHQCPVWSLNQGCCLLWKTHPQMAPACAWSLSTFSCAWPPPSFVGCLIPTEASFQGWR
    

Molecular Weight53665.83 Da

Isoelectric Point (pI)6.53

Net Charge (pH 7.0)-2.33

Net Charge (pH 7.4) -3.50

Charge Density (pH 7.0) -0.0047

GRAVY Index0.28

Hydrophobic Moment 0.71

Boman Index0.22

Instability Index44.42

Aliphatic Index 105.80

Aromaticity 0.0913

Extinction Coeff. Reduced 80900.00

Extinction Coeff. Oxidized 81525.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0147528 VERIFIED: NO

Provenance & Taxonomy

OrganismVombatus ursinus [Bacterium]

FamilyBPI

Tax ID29139

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence