Peptide Database

Peptide NameSLAY-screened peptide P2795

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC112H149N29O27S

DescriptionStandard

        PSWGCWDHFHAWANLPINIT
    

Molecular Weight2365.62 Da

Isoelectric Point (pI)5.99

Net Charge (pH 7.0)-0.88

Net Charge (pH 7.4) -1.05

Charge Density (pH 7.0) -0.0438

GRAVY Index-0.15

Hydrophobic Moment 0.35

Boman Index0.31

Instability Index44.69

Aliphatic Index 68.50

Aromaticity 0.2000

Extinction Coeff. Reduced 16500.00

Extinction Coeff. Oxidized 16500.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 862.11

LogP -4.78

H-bond Donors 31.0

H-bond Acceptors 29.0

Rotatable Bonds 65.0

Heavy Atoms 169.0

Ring Count 11.0

Amide Bonds 21.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0376547 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/