Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length473 amino acids

Chemical FormulaC2347H3661N597O673S24

DescriptionStandard

        MLPLVAVVLMLISFSRGQNPAVQVILTDKGLQYAKHVGAGWIQEKLDHVTLPDISGKIMGIIDYTFSGVTVTKCNFPEPSVEFYQNATGFKSSISGLSVAVTGVWMTHCGLINDRGSFNMAIFNMDVSSVVELGKDAEGHLSVASVHCEAQVGNVDMQFRGGASWIFRPFVKHFKRCIKADIKAAICPYVEESIMNLEYHLQAMNVSFDVDDNFTFELPLTGVPVINASSLNLGLKGEFYNIKTHTEPPFKAQPFSVPEQPDYMLSVGLSEFTLNSASYVLYSAGLLQAVITDSMIPPNLHLHLNTSWMRPYIPQLPKMFPGLLMDLQIYAREVPMFSFQPGVVKLGFQGAVKAFAIQPNGTRTPLFKLNTDSKLSGKVWLAGGRLKGSVALENFTLTLADSEVGPFETDSLEHLMKTGMMIAVEKLNVELGEGVVLPRMLHAELVNTVLGVEEGFIAISSDAQVVATDRGFN
    

Molecular Weight51778.33 Da

Isoelectric Point (pI)5.57

Net Charge (pH 7.0)-10.44

Net Charge (pH 7.4) -11.45

Charge Density (pH 7.0) -0.0221

GRAVY Index0.18

Hydrophobic Moment 0.91

Boman Index0.19

Instability Index27.11

Aliphatic Index 95.98

Aromaticity 0.0930

Extinction Coeff. Reduced 43890.00

Extinction Coeff. Oxidized 44140.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0023209 VERIFIED: NO

Provenance & Taxonomy

OrganismLiparis tanakae [Bacterium]

FamilyBPI

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence