Peptide Database

Peptide NameKininogen-1

Function Ontology

Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory

Membrane / Ion-channel modulation ▸ Ion channel modulation

Neurological / Signaling ▸ Neuromuscular and muscle activity ▸ Myotropic activity

Regulatory peptide ▸ Biological modulation

Standard StatusStandard

Sequence Length40 amino acids

Chemical FormulaC208H316N56O82

DescriptionStandard

        EEEKRDTEEEENDDEIEEESEEKKREAPERPPGFTPFRIY
    

Molecular Weight4913.06 Da

Isoelectric Point (pI)4.20

Net Charge (pH 7.0)-11.12

Net Charge (pH 7.4) -11.33

Charge Density (pH 7.0) -0.2781

GRAVY Index-2.25

Hydrophobic Moment 0.35

Boman Index-0.56

Instability Index141.34

Aliphatic Index 22.00

Aromaticity 0.0750

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1490.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 2284.13

LogP -23.03

H-bond Donors 75.0

H-bond Acceptors 71.0

Rotatable Bonds 169.0

Heavy Atoms 346.0

Ring Count 7.0

Amide Bonds 40.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0011733 VERIFIED: YES

Provenance & Taxonomy

OrganismPhyllomedusa sauvagii [Animal]

FamilyKininogen

Tax ID8395

Structure & Mods

Configlinear peptide [Linear]

Chiralitynoncanonical stereochemical modification [Modified]

Other Mods32:4-hydroxyproline; 40:Sulfotyrosine

Bio-Activity Profile

Function

Myotropic Enzyme modulation Ion channel modulation Receptor modulation ACE inhibitory

Activity1.6 μM

MethodKi

Half-LifeMammalian: 1 hour; Yeast: 30 min; E. coli: >10 hour

RECORD: Rec_0169127 VERIFIED: YES