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MYP_099813
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Basic Information
Nisin A
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Standard
34 amino acids
C143H249N41O46S6
Standard
Sequence
ITSISLCTPGCKTGVLMGCNLKTATCNCSVHVSK
Physicochemical Analysis
3471.14 Da
8.78
2.79
2.46
0.0822
0.52
0.29
0.18
13.45
85.88
0.0000
0.00
250.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1389.82
-19.61
54.0
56.0
114.0
236.0
2.0
35.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0072019 VERIFIED: YES
Provenance & Taxonomy
Lactococcus lactis [Bacterium]
Bacteriocin
Structure & Mods
DNA-encoded linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0090094 VERIFIED: YES
Provenance & Taxonomy
Lactococcus lactis [Bacterium]
Bacteriocin
1358
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
1750-1755, 2008) revealed multiple post-translational modifications: T2 to Dhb2 (dehydrated); S5, Dha (dehydrated); T8, T23, T25, all to Abu; S33, to Dha. In addition, residues 3,7; 8,11; 13,19; 23,26; 25,28 are covalently linked via a sulfur (thioether). Similar covalent links occur in nisin A (AP00205) and nisin Z (AP00204)
Bio-Activity Profile
Antimicrobial
PaperPurification and biological characterization of halocin C8, a novel Identification of the lantibiotic nisin Q, a new natural nisin variant produced by Lactococcus lactis 61-14 isolated from a river in Japan.
RECORD: Rec_0102266 VERIFIED: YES
Provenance & Taxonomy
Lactococcus lactis [Bacterium]
Bacteriocin
1358
Structure & Mods
thioether-constrained cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
None
None
There are two dehydroalanines (S5; S33), one dehydrobutyrine (T2), which form one lanthionine (S3-C7) and four β-methyllanthionines (T8-C11; T13-C19; T23-C26; T25-C28)
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
LAB
PaperPubMed PMID: 12913315 PMID12913315 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12913315/
RECORD: Rec_0169381 VERIFIED: YES
Provenance & Taxonomy
Lactococcus lactis [Bacterium]
Bacteriocin
1358
Structure & Mods
thioether-constrained cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
None
None
There are two dehydroalanines (S5; S33), one dehydrobutyrine (T2), which form one lanthionine (S3-C7) and four β-methyllanthionines (T8-C11; T13-C19; T23-C26; T25-C28)
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Bacillus sp
PaperPubMed PMID: 12913315 PMID12913315 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12913315/
RECORD: Rec_0181483 VERIFIED: NO
Provenance & Taxonomy
Lactococcus lactis [Bacterium]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
PaperNisin Q Evidence URLhttps://www.uniprot.org/uniprotkb/Q76HP8/entry
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