Peptide Database

Peptide NameUnnamed

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antiviral

Antiviral ▸ Anti-Herpesvirus ▸ Anti-HSV

Antiviral ▸ Anti-HIV

Antiviral ▸ Anti-HIV ▸ Anti-HIV-1

Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition

Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition ▸ Entry inhibitor

Standard StatusStandard

Sequence Length18 amino acids

Chemical FormulaC78H145N33O19S6

DescriptionStandard

        GICRCICGRRICRCICGR
    

Molecular Weight2041.59 Da

Isoelectric Point (pI)9.30

Net Charge (pH 7.0)4.70

Net Charge (pH 7.4) 4.41

Charge Density (pH 7.0) 0.2611

GRAVY Index0.52

Hydrophobic Moment 0.77

Boman Index-0.22

Instability Index36.55

Aliphatic Index 86.67

Aromaticity 0.0000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 375.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 867.52

LogP -10.39

H-bond Donors 40.0

H-bond Acceptors 30.0

Rotatable Bonds 69.0

Heavy Atoms 136.0

Ring Count 0.0

Amide Bonds 17.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0368250 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyDefensin

Tax ID32630

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Disulfide3-16, 5-14, 7-12

Other ModsDisulfide bonds between Cys3 and Cys16,Cys5 and Cys14,Cys7 and Cys12.

Bio-Activity Profile

Function

Antiviral Anti-HIV-1 Entry inhibition

TargetHIV-1 C | JC53-BL cells

Activity3.32±0.76 μg/mL

MethodIC50

Half-LifeMammalian: 30 h; Yeast: >20 h; E. coli: >10 h

PaperRetrocyclin: a primate peptide that protects cells from infection by T- and M-tropic strains of HIV-1 | Wang W, Owen SM, Rudolph DL, Cole AM, Hong T, Waring AJ, Lal RB, Lehrer RI. | J Immunol. 2004 Jul 1;173(1):515-20. | DOI:10.4049/jimmunol.173.1.515 | PMID:15210812 PMID15210812 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15210812/

RECORD: Rec_0374386 VERIFIED: YES

Provenance & Taxonomy

OrganismPrimates [Animal]

FamilyDefensin

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Other ModsBackbone-cyclized theta-defensin scaffold

Bio-Activity Profile

Function

Antiviral Entry inhibitor

TargetHerpes simplex virus 1 (Virus entry); ME-180

MethodMTT assay

PaperTheta defensins protect cells from infection by herpes simplex virus by inhibiting viral adhesion and entry. | Yasin B, Wang W, Pang M, Cheshenko N, Hong T, Waring AJ, Herold BC, Wagar EA, Lehrer RI. | J Virol. 2004 | PMID:15113897 PMID15113897 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15113897/

RECORD: Rec_0422757 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Confighead-to-tail cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide3-16; 5-14; 7-12

Bio-Activity Profile

Function

Antimicrobial

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