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MYP_099804
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Basic Information
Unnamed
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antiviral
Antiviral ▸ Anti-Herpesvirus ▸ Anti-HSV
Antiviral ▸ Anti-HIV
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition ▸ Entry inhibitor
Standard
18 amino acids
C78H145N33O19S6
Standard
Sequence
GICRCICGRRICRCICGR
Physicochemical Analysis
2041.59 Da
9.30
4.70
4.41
0.2611
0.52
0.77
-0.22
36.55
86.67
0.0000
0.00
375.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
867.52
-10.39
40.0
30.0
69.0
136.0
0.0
17.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0115264 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
PaperAVPdb: a database of experimentally validated antiviral peptides targeting medically important viruses PMID24285301 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24285301/
RECORD: Rec_0120041 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Defensin
32630
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
Bio-Activity Profile
Antiviral
primary isolates of HIV-1. The molecule can self associate in water in a concentration dependent manner. Structure: In 2007, a low-resolution structure was initially determined in the presence of SDS micelles (PDB ID: 2ATG). In 2012, a high-resolution structure was determined in water (Conibear AC et al., 2012). You can rotate, zoom
PaperActivity of alpha- and theta-defensins against primary isolates of HIV-1.
RECORD: Rec_0128735 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Anti-Gram-negative
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0172355 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Retrocyclin
32630.0
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
mixed L/D amino-acid peptide [Mixed]
Bio-Activity Profile
Antiviral Anti-HIV Anti-HSV
HIV-1, HSV-1, HSV-2
PaperRetrocyclins: Antiviral and Antimicrobial Peptides Evidence URLhttps://patents.google.com/patent/US20090264344A1/en PatentUS 2009/0264344 A1
RECORD: Rec_0188541 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Defensin
32630
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
3-16, 5-14, 7-12
Disulfide bonds between Cys3 and Cys16,Cys5 and Cys14,Cys7 and Cys12.
Bio-Activity Profile
Antiviral Anti-HIV-1 Entry inhibition
HIV-1 G | JC53-BL cells
3.06±0.43 μg/mL
IC50
Mammalian: 30 h; Yeast: >20 h; E. coli: >10 h
PaperRetrocyclin: a primate peptide that protects cells from infection by T- and M-tropic strains of HIV-1 | Wang W, Owen SM, Rudolph DL, Cole AM, Hong T, Waring AJ, Lal RB, Lehrer RI. | J Immunol. 2004 Jul 1;173(1):515-20. | DOI:10.4049/jimmunol.173.1.515 | PMID:15210812 PMID15210812 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15210812/
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