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MYP_099803
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Basic Information
PN-AMP1
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Standard
41 amino acids
C168H267N61O58S8
Standard
Sequence
QQCGRQASGRLCGNRLCCSQWGYCGSTASYCGAGCQSQCRS
Physicochemical Analysis
4325.81 Da
8.76
3.68
3.36
0.0897
-0.52
0.43
-0.15
35.72
26.34
0.0732
8480.00
8980.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1974.41
-33.72
79.0
70.0
142.0
295.0
4.0
47.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0040500 VERIFIED: YES
Provenance & Taxonomy
Ipomoea nil [Plant]; Pharbitis nil [Plant]
Hevein
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
disulfide bond reported, sites not specified
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Yeast
Fusarium oxysporum
200 μg/mL
MIC
PaperPubMed PMID 9507071 | Montesinos E 2007 FEMS Microbiol Lett 270, 1-11 PMID9507071 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/9507071/
RECORD: Rec_0050241 VERIFIED: YES
Provenance & Taxonomy
Japanese morning glory [Plant]
Hevein-like
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Compared to Pn-AMP2 (APD entry 1052), Pn-AMP1 contains one additional residue (Ser) at the C-terminus. Rich in G; Chemical modification: contains four disulfide bonds
Bio-Activity Profile
Antimicrobial Antifungal
activity was substantially reduced
>200 μg/mL
IC50
PaperTwo hevein homologs isolated from the seed of Pharbitis nil L. exhibit potent antifungal activity.
RECORD: Rec_0086937 VERIFIED: YES
Provenance & Taxonomy
Ipomoea nil [Animal]
Defensin
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Disulfide bond(s) reported
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Antifungal
Fungi (Medium A, Medium A+): Botrytis cinerea
16 μg/mL
IC50
PaperPubMed PMID: 9507071 PMID9507071 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/9507071/
RECORD: Rec_0087079 VERIFIED: YES
Provenance & Taxonomy
Ipomoea nil [Plant]; Pharbitis nil [Plant]
Hevein
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
disulfide bond reported, sites not specified
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Yeast
Sclerotinia sclerotiorum
11 μg/mL
MIC
PaperPubMed PMID 9507071 | Montesinos E 2007 FEMS Microbiol Lett 270, 1-11 PMID9507071 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/9507071/
RECORD: Rec_0087412 VERIFIED: YES
Provenance & Taxonomy
Ipomoea nil [Plant]; Pharbitis nil [Plant]
Hevein
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
disulfide bond reported, sites not specified
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Yeast
Rhizoctonia solani
200 μg/mL
MIC
PaperPubMed PMID 9507071 | Montesinos E 2007 FEMS Microbiol Lett 270, 1-11 PMID9507071 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/9507071/
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