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MYP_099786
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Basic Information
Feleucin-2 (toads, amphibians, animals)
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Standard
27 amino acids
C119H200N34O32
Standard
Sequence
GIGGALLNVGKVALKGLAKGLAEHFAN
Physicochemical Analysis
2619.07 Da
9.70
1.85
1.59
0.0684
0.59
0.54
0.33
-17.59
126.67
0.0370
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1050.14
-9.31
35.0
35.0
90.0
185.0
2.0
28.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0010056 VERIFIED: YES
Provenance & Taxonomy
Bombina variegata [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Staphylococcus aureus
8 mg/L, MBC=32 mg/L
MIC
PMID25003126 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25003126/
RECORD: Rec_0017675 VERIFIED: YES
Provenance & Taxonomy
Bombina variegata [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Candida albicans
32 mg/L, MBC=32 mg/L
MIC
PMID25003126 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25003126/
RECORD: Rec_0032793 VERIFIED: YES
Provenance & Taxonomy
Bombina variegata [Animal]
Bombinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Escherichia coli NCTC 10418
32 μg/mL
MIC
PMID25003126 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25003126/
RECORD: Rec_0047411 VERIFIED: YES
Provenance & Taxonomy
Bombina variegata [Animal]
Bombinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Staphylococcus aureus NCTC 10788
8 μg/mL
MIC
PMID25003126 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25003126/
RECORD: Rec_0069992 VERIFIED: YES
Provenance & Taxonomy
Bombina variegata [Animal]
Bombinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
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